Clinical study

Immune- and proinflammatory response in critically ill patients with endothelial damage. A sub-study of ENDO-OMICS.

  • Research area: Intensive therapy

  • Primary investigator: Caroline Humble

Immune- and proinflammatory response in critically ill patients with endothelial damage. A sub-study of ENDO-OMICS.

A Danish, multicenter, prospective, exploratory, observational cohort study where we will collect and analyse blood samples and clinical data on 1,000 critically ill patient.

In Denmark up to one third of the patients (~10,000) admitted to an intensive care unit (ICU)die annually due to multi organ dysfunction syndrome (MODS). Research within the last ten years has shown that shock-induced damage to the endothelial cells (the cells that line the blood vessels throughout the body) is pivotal in the development of MODS and mortality in critically ill patients.

In this PhD study we will collect and analyse blood samples and clinical data on 1,000 critically ill patients from six intensive care units in Eastern Denmark to characterise the potential relationship between endothelial damage, the immune- and proinflammatory response, and different types and severity of MODS/organ failure.

We expect this explorative study to generate hypotheses for future randomised controlled trials targeted towards MODS and mortality. Ultimately, our goal is to improve the treatment and survival of critically ill patients by personalised medicine. The PhD study is a sub-study of the main study ENDO-OMICS, and will be carried out at the Department of Anaesthesiology, Zealand University Hospital, Koege in collaboration with Clinical Academic Group (CAG) Center for Endotheliomics.

Status: Patient inclusion completed.

Information about ENDO-OMICS:www.gchsp.dk/cag/cag-center-for-endotheliomics