Clinical study

Effect of Combinations of Paracetamol, Ibuprofen, and Dexamethasone on Patient-Controlled Morphine Consumption in the First 24 Hours After Total Hip Arthroplasty. The RECIPE Randomized Clinical Trial

  • Research area: Postoperative pain

  • Primary investigator: Joakim Steiness

A large randomized clinical trial focusing on optimizing the basal pain treatment for patients with an artificial hip inserted.

Treatment of acute pain after an operation is crucial for the final result – also in the long term. Opioids (morphine, oxycodone, tramadol, etc.) are effective painkillers used daily but carry a risk of several inappropriate side effects. In addition, more or less advanced methods have been developed for exercising pain coverage, but these are typically invasive and cause temporary immobilization and increased monitoring needs.

Therefore, based on the above, it is desirable to put together a primary painkiller treatment that provides the most possible effect and the fewest possible side effects. In RECIPE, we investigate the analgesic and opioid-sparing impact of four different combinations of known and frequently used drugs in the form of paracetamol, ibuprofen and dexamethasone. We do this in 1,060 patients who must have an artificial hip inserted. All patients receive full pain coverage – the interesting thing is how much opioid it takes to achieve this.

RECIPE is one of the most extensive acute pain studies worldwide, and we hope to contribute to the design of better postoperative pain treatment. The study runs at seven hospitals in three regions, and you can read more about the trial at RECIPE is independently supported by the Novo Nordisk Foundation and Næstved-Slagelse-Ringsted Hospital’s research fond.